This 60-day RCT in 59 moderately stressed adults found that standardized ashwagandha (240 mg/day) reduced perceived stress (PSS) versus placebo and improved anxiety and sleep-related measures. The intervention was well tolerated. Results align with prior stress/anxiety data for ashwagandha, though modest sample size and single-dose design suggest further dose-ranging and durability work.


Ashwagandha root extract reduces perceived stress and anxiety in healthy adults

In a 12-week placebo-controlled RCT in older men, daily 250 mg NMN raised NAD+ and improved some markers of muscle function without safety issues, supporting NMN’s role in human NAD+ metabolism.

This RCT strengthens evidence that NMN can elevate NAD+ safely in aging humans, showing functional gains consistent with preclinical findings. Further large-scale and long-term trials are warranted.

Chronic nicotinamide mononucleotide supplementation elevates NAD+ in older men: a randomized, placebo-controlled trial

In a multicenter, randomized, double-blind trial of patients with chronic HF (NYHA III–IV), CoQ10 (300 mg/day) added to guideline therapy reduced major adverse cardiovascular events and cardiovascular mortality versus placebo over a median 2-year follow-up.


Q-SYMBIO randomized 420 NYHA III–IV HF patients to CoQ10 (300 mg/day) or placebo on top of standard therapy and followed them for approximately two years. CoQ10 significantly lowered the risk of major adverse cardiovascular events and cardiovascular mortality, with an acceptable safety profile. While some attrition and era effects limit generalization, results support CoQ10 as a potential adjunct in chronic heart failure management.


Coenzyme Q10 reduces adverse cardiovascular events in chronic heart failure (Q-SYMBIO)

In an 8-week, randomized, double-blind, placebo-controlled trial (n=101), Curcugen® (1000 mg/day) produced statistically significant reductions in KOOS pain and numeric pain ratings, with favorable trends on functional outcomes. The product was well tolerated.


This 8-week RCT in 101 adults with radiographic knee OA tested Curcugen® 1000 mg/day versus placebo. Curcugen® resulted in greater reductions in KOOS pain and numeric pain ratings and showed advantages on several functional measures. The extract was well tolerated. While the trial was relatively short and used a single brand, findings support curcumin’s short-term analgesic and functional benefits in knee OA.


Curcumin extract (Curcugen®) reduces knee osteoarthritis pain vs placebo

This randomized, double-blind, placebo-controlled study evaluated the effects of a bioavailability-enhanced curcumin supplement (1000–1500 mg/day) in 120 adults with mild knee discomfort over an eight-week period. Results showed a 32% reduction in CRP compared to placebo and statistically significant improvements in joint pain and flexibility. The supplement was well tolerated with no serious adverse events. Limitations include short duration and single-center design. More research is needed on longer-term effects and in broader populations.


This randomized controlled trial evaluated a bioavailability-enhanced curcumin supplement in adults with mild knee discomfort. Participants taking curcumin experienced significantly lower C-reactive protein levels (a marker of inflammation) and improved mobility scores compared to placebo. The findings support curcumin’s anti-inflammatory potential and joint comfort benefits.  However, longer-term, multi-center trials are needed to confirm durability of effect and generalizability.


Curcumin supplementation reduces inflammation in adults with joint discomfort

This 60-day randomized, double-blind, placebo-controlled study in 66 adults aged 40–65 found that 300 mg/day NMN (Uthever®) significantly raised NAD+ levels and improved well-being compared to placebo without adverse effects.

The trial demonstrates NMN’s NAD+-boosting potential and safety at 300 mg/day. While encouraging, longer and multi-dose studies are needed to confirm broader metabolic or longevity outcomes.

Efficacy and safety of Uthever® nicotinamide mononucleotide supplementation in middle-aged and older adults: a randomized, double-blind, placebo-controlled trial

A randomized, double-blind, placebo-controlled trial in 30 adults with MCI found that daily ingestion of Hericium erinaceus improved cognitive test scores over 16 weeks versus placebo. Scores tended to decline during a 4-week washout. Lion’s Mane was well tolerated with no serious adverse events.


This landmark RCT suggests Lion’s Mane can modestly improve cognitive performance in MCI when taken continuously (3 g/day). The benefit attenuated after discontinuation, implying effects may depend on ongoing intake. Despite a small, single-center sample, the study is methodologically sound (randomized, double-blind, placebo-controlled) and aligns with preclinical neurotrophic findings for Hericium erinaceus. Larger, longer, and more diverse trials are needed to confirm durability and clinical relevance.


Improvement of cognitive function in adults with mild cognitive impairment with Hericium erinaceus

In a supervised 8-week resistance training program (n≈57), KSM-66 ashwagandha (600 mg/day) improved maximal strength (bench and squat), increased muscle size, elevated serum testosterone, and reduced markers of exercise-induced muscle damage versus placebo. Findings support an ergogenic role for standardized ashwagandha in trained young men, with the caveat of brand-specificity and limited generalizability.


KSM-66® ashwagandha improves strength, muscle size, and testosterone in resistance-trained men

VITAL randomized 25,871 generally healthy adults to omega-3, vitamin D3, both, or placebo and followed them for a median ~5.3 years. Omega-3 did not significantly reduce the composite of major CVD events overall, but myocardial infarction was lower in certain subgroups (e.g., low fish intake). Safety was acceptable. Findings suggest limited primary-prevention benefit in average-risk adults, with potential benefit in select subgroups.


Marine omega-3 fatty acids for primary prevention — VITAL trial

In an 8-week, double-blind RCT of elderly patients with primary insomnia, oral magnesium improved multiple sleep measures (ISI, efficiency, total sleep time, latency) and shifted hormonal markers in a direction consistent with improved sleep. As the formulation was magnesium oxide and the cohort was elderly, results may not generalize to other forms or ages.


Oral magnesium improves subjective insomnia measures in older adults

This double-blind RCT in adults with cancer-related fatigue found that standardized Panax ginseng improved fatigue severity versus placebo over eight weeks, with supportive changes in quality-of-life/mood measures. Interpretation is tempered by heterogeneous cancer types and pragmatic dose/form considerations.


Panax ginseng extract reduces cancer-related fatigue vs placebo

In a 4-week RCT, 730 mg/day quercetin lowered systolic and diastolic blood pressure versus placebo among adults with stage-1 hypertension, with no major adverse events. Short duration and modest sample size limit conclusions about longer-term BP control and generalizability.


Quercetin reduces blood pressure in stage-1 hypertensive adults

A randomized, double-blind, placebo-controlled dose-dependent clinical trial in 80 healthy middle-aged adults found that NMN supplementation at 300 mg/day, 600 mg/day, or 900 mg/day for 60 days was safe and well tolerated, produced dose-dependent increases in blood NAD+ concentrations, improved 6-minute walking distance, and prevented the rise in biological age seen in placebo, though no effect on insulin resistance (HOMA-IR) was observed.

This human trial shows that NMN can safely raise systemic NAD+ and improve physical performance in healthy adults, reinforcing preclinical findings. However, the trial was short, and effects on clinical endpoints (insulin resistance, aging-related disease) remain unproven—larger, longer, and clinical-population trials are warranted.

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, double-blind, placebo-controlled dose-dependent trial

Ashwagandha (KSM-66)

Chandrasekhar K, et al. High-concentration, full-spectrum Ashwagandha root extract reduces stress/anxiety. Indian J Psychol Med. 2012.

Langade D, et al. Ashwagandha root extract for insomnia and anxiety: double-blind, randomized. Cureus. 2019.

Root extract standardized for withanolides, studied for stress resilience, cortisol reduction, and sleep quality.

Bovine Colostrum

Concentrated early-milk proteins (IgG, growth factors) for gut and immune support.

Calcium

Tang BM, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007.

Weaver CM, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2012.

Essential mineral for bone strength, nerve signaling, and muscle contraction — foundational for skeletal health, especially in women post-menopause.

Cistanche

Traditional adaptogenic herb explored for vitality and cognitive support; human data limited.

Copper

Trace mineral for iron transport, antioxidant enzymes, and connective tissue.

CoQ10 (Ubiquinone/Ubiquinol)

Mitochondrial electron carrier and antioxidant; supports statin-associated myalgias and cardiac function.

Curcumin C3 Complex®

Curcumin for osteoarthritis: systematic review/meta-analysis. Phytother Res. 2016.

Curcumin and inflammation: meta-analysis of RCTs. Nutrients. 2018.

Standardized curcuminoid complex; bioavailability often enhanced by piperine or phospholipids. Studied for inflammation, joint comfort, and antioxidant support.

Fenugreek

Seed/extract used for glucose control, lactation, and libido formulations.

Fisetin

Flavonoid investigated for senolytic and neuroprotective properties (human data limited).

Folate (5-MTHF / Methylfolate)

MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the MRC Vitamin Study. Lancet. 1991.

Homocysteine and B vitamins in cardiovascular disease risk. Am J Clin Nutr. 2005.

Active folate that supports fetal neural tube development, methylation, and red blood cell formation — a cornerstone for preconception and pregnancy care.

Ginseng (Panax)

Adaptogenic root studied for fatigue, cognitive performance, and glucose modulation.

Iron

Pena-Rosas JP, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015.

Petry N, et al. The prevalence of iron deficiency and anemia in women. Nutrients. 2016.

Essential trace mineral for oxygen transport, energy metabolism, and red blood cell production — particularly important for women of reproductive age.

L-Arginine

L-arginine and endothelial function—overview of clinical data

Amino acid and nitric-oxide precursor studied for endothelial function, circulation, and exercise performance in select contexts.

Lion's Mane (Hericium erinaceus)

Culinary-medicinal mushroom for cognitive and nerve support.

Magnesium (Glycinate)

Abbasi B, et al. Magnesium supplementation and primary insomnia in elderly: double-blind RCT. J Res Med Sci. 2012.

Boyle NB, et al. Effects of magnesium supplementation on anxiety/stress: review/meta-analysis. Nutrients. 2017.

Gentle chelated form; commonly used for sleep quality, relaxation, and muscle comfort. High bioavailability with minimal GI disturbance.

Niacin (Vitamin B3)

Supports NAD+ metabolism; high-dose forms used for lipid modulation.

NMN (Nicotinamide Mononucleotide)

NAD+ precursor examined for metabolic and cellular energy support.

Olive Extract (Oleuropein/Hydroxytyrosol)

Polyphenol-rich extract studied for cardiometabolic and antioxidant effects.

Omega-3 (EPA/DHA)

Bhatt DL, et al. Icosapent ethyl and cardiovascular risk reduction (REDUCE-IT). N Engl J Med. 2019.

Sublette ME, et al. Omega-3 PUFAs and depression: meta-analysis. Mol Psychiatry. 2016.

Triglyceride or re-esterified triglyceride forms of omega-3 fatty acids supporting cardiovascular, cognitive, and mood health.

Plant Sterols/Stanols

Phytosterols that reduce intestinal cholesterol absorption; used for LDL lowering.

PQQ (Pyrroloquinoline Quinone)

Redox cofactor-like compound explored for mitochondrial biogenesis and neuro support.

Pterostilbene

Stilbene compound related to resveratrol with higher bioavailability; antioxidant/metabolic research.

Quercetin

Flavonoid with antioxidant and mast-cell stabilizing properties; often paired with bromelain/vitamin C.

Saw Palmetto (Serenoa repens)

Liposterolic extract studied for LUTS/BPH symptom relief.

Selenium

Trace mineral for antioxidant enzymes (GPx) and thyroid hormone metabolism.

Spermidine

Polyamine linked to autophagy and healthy aging markers; human supplement data emerging.

TMG (Trimethylglycine; Betaine)

Methyl donor supporting homocysteine metabolism and liver osmoregulation.

Tongkat Ali (Eurycoma longifolia)

Root extract studied for stress, libido, and training adaptations.

Turkesterone (Ecdysteroid)

Plant ecdysteroid marketed for performance/body composition; human data limited.

Vitamin A (Retinol/Carotenoids)

Vision, immune, and epithelial health; retinoids vs provitamin A carotenoids.

Vitamin B12 (Cobalamin)

Essential for methylation and RBC/nerve health; malabsorption is common.

Vitamin C (Ascorbic Acid)

Water-soluble antioxidant supporting immune function, collagen synthesis, and iron absorption.

Vitamin D3 (Cholecalciferol)

Bischoff-Ferrari HA, et al. Fracture prevention with vitamin D supplementation. JAMA. 2005.

Martineau AR, et al. Vitamin D supplementation to prevent acute respiratory infections. BMJ. 2017.

Hormone-like vitamin that regulates calcium absorption, bone health, muscle function, and immune signaling — especially important for women across pregnancy and menopause.

Vitamin E (Tocopherols/Tocotrienols)

Lipid-phase antioxidant; mixed forms may offer broader activity.

Vitamin K2 (MK-7)

Knapen MHJ, et al. Three-year low-dose vitamin K2 (MK-7) supplementation improves bone strength in postmenopausal women. Osteoporos Int. 2013.

Knapen MHJ, et al. Vitamin K2 supplementation and arterial stiffness. Thromb Haemost. 2015.

Orchestrates calcium placement — activates proteins that move calcium into bones and keep it out of arteries; essential complement to Vitamin D3 for women’s bone health.

Zinc

Trace mineral for immune function, enzymes, and skin health.

Research Studies

Ingredients