Ashwagandha (KSM-66)
Plain-language research summary.
Detail
adaptogenstresssleepmood
Root extract standardized for withanolides, studied for stress resilience, cortisol reduction, and sleep quality.
Common Dietary Sources
- Roots of *Withania somnifera* (Indian ginseng)
- Traditional Ayurvedic preparations (churna, tonics)
How the Body Uses It
Withanolides appear to modulate the hypothalamic–pituitary–adrenal (HPA) axis and GABAergic signaling, which may reduce perceived stress and support sleep quality.
Supplement Origins
KSM-66 is a root-only extract standardized for withanolides. Sensoril uses a root+leaf blend with higher withanolide content; profiles differ slightly.
Possible Uses
- Reduce day-to-day stress and anxiousness
- Support sleep quality and faster sleep onset
- General adaptogenic support during demanding periods
Long-Term Use
Well-tolerated in RCTs up to ~12 weeks. Consider periodic breaks and discuss longer use with a clinician, especially with thyroid conditions.
Dose Guidance
Studied
300–600 mg/day (root extract)
Commonly split AM/PM; evening dose often preferred for sleep.
Forms
KSM-66® Ashwagandha (root extract)
Standardization: ≥5% withanolides
Sensoril® Ashwagandha (root + leaf)
Standardization: ≥10% withanolides
Delivery
Coming soon.
Evidence & Studies
Reduced cortisol and perceived stress in chronically stressed adults
References
Safety & Cautions
Cautions
- May cause mild drowsiness in sensitive individuals
Contraindications
- Pregnancy
- Hyperthyroidism
Interactions
- May potentiate thyroid medication
- May enhance sedative/GABAergic effects